First Appearance: Batman Arkham Asylum
The antidote is a plant spore that grows deep beneath Arkham Island, within Killer Croc's lair, which Poison Ivy says that is the only way to reverse the affect of the Titan Strain.
Batman retrieves the spores from Croc's Lair and takes them to the Arkham Batcave to try and reverse manufacture the cure. However he is only able to make one dose of the anti- compound partly due to the speed it takes, as the process takes a long time and partly as the spores he collected wasn't enough. Poison Ivy's plants also smash through the Batcave, destroying the Batcomputer and every other way of manufacturing the cure.
Later Batman uses the antidote on himself, after jumping in front of a Titan dart that was meant for Gordon, forcing him to find a different way to stop the Joker, who injected himself with Titan.
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